Chemogenetic fingerprinting by analysis of cellular growth dynamics

@article{Warringer2008ChemogeneticFB,
  title={Chemogenetic fingerprinting by analysis of cellular growth dynamics},
  author={Jonas Warringer and Dragi Anevski and Beidong Liu and Anders Blomberg},
  journal={BMC Chemical Biology},
  year={2008},
  volume={8},
  pages={3 - 3}
}
BACKGROUND A fundamental goal in chemical biology is the elucidation of on- and off-target effects of drugs and biocides. To this aim chemogenetic screens that quantify drug induced changes in cellular fitness, typically taken as changes in composite growth, is commonly applied. RESULTS Using the model organism Saccharomyces cerevisiae we here report that resolving cellular growth dynamics into its individual components, growth lag, growth rate and growth efficiency, increases the predictive… CONTINUE READING
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Both in terms of drug - drug and gene - drug interactions did the individual growth variables capture distinct and only partially overlapping aspects of cell physiology .
Both in terms of drug - drug and gene - drug interactions did the individual growth variables capture distinct and only partially overlapping aspects of cell physiology .
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