Chemogenetic Synaptic Silencing of Neural Circuits Localizes a Hypothalamus→Midbrain Pathway for Feeding Behavior

@article{Stachniak2014ChemogeneticSS,
  title={Chemogenetic Synaptic Silencing of Neural Circuits Localizes a Hypothalamus→Midbrain Pathway for Feeding Behavior},
  author={Tevye J E Stachniak and Anirvan Ghosh and Scott M Sternson},
  journal={Neuron},
  year={2014},
  volume={82},
  pages={797-808}
}
  • Tevye J E Stachniak, Anirvan Ghosh, Scott M Sternson
  • Published in Neuron 2014
  • Biology, Medicine
  • Brain function is mediated by neural circuit connectivity, and elucidating the role of connections is aided by techniques to block their output. We developed cell-type-selective, reversible synaptic inhibition tools for mammalian neural circuits by leveraging G protein signaling pathways to suppress synaptic vesicle release. Here, we find that the pharmacologically selective designer Gi-protein-coupled receptor hM4D is a presynaptic silencer in the presence of its cognate ligand clozapine-N… CONTINUE READING

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