Chemogenetic Characterization of Inositol Phosphate Metabolic Pathway Reveals Druggable Enzymes for Targeting Kinetoplastid Parasites.

@article{Cestari2016ChemogeneticCO,
  title={Chemogenetic Characterization of Inositol Phosphate Metabolic Pathway Reveals Druggable Enzymes for Targeting Kinetoplastid Parasites.},
  author={Igor Eduardo Dias Cestari and Paige Haas and Nilmar Silvio Moretti and Sergio Schenkman and Kenneth D. Stuart},
  journal={Cell chemical biology},
  year={2016},
  volume={23 5},
  pages={
          608-617
        }
}
Kinetoplastids cause Chagas disease, human African trypanosomiasis, and leishmaniases. Current treatments for these diseases are toxic and inefficient, and our limited knowledge of drug targets and inhibitors has dramatically hindered the development of new drugs. Here we used a chemogenetic approach to identify new kinetoplastid drug targets and inhibitors. We conditionally knocked down Trypanosoma brucei inositol phosphate (IP) pathway genes and showed that almost every pathway step is… CONTINUE READING
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