Chemoenzymatic synthesis of functionalized cyclohexylglycines and alpha-methylcyclohexylglycines via Kazmaier-Claisen rearrangement.

Abstract

The synthesis of homochiral functionalized cyclohexylglycines and alpha-methylcyclohexylglycines via chelated Kazmaier-Claisen rearrangement is described. These were shown to be potent scaffolds for the development of MMP inhibitors.

Cite this paper

@article{Hudlicky2001ChemoenzymaticSO, title={Chemoenzymatic synthesis of functionalized cyclohexylglycines and alpha-methylcyclohexylglycines via Kazmaier-Claisen rearrangement.}, author={Tomas Hudlicky and Kwasi Oppong and C Duan and Chloe Stanton and Matthew J Laufersweiler and Michael G Natchus}, journal={Bioorganic & medicinal chemistry letters}, year={2001}, volume={11 5}, pages={627-9} }