Chemoenzymatic synthesis of classical and non-classical anticoagulant heparan sulfate polysaccharides.

@article{Kuberan2003ChemoenzymaticSO,
  title={Chemoenzymatic synthesis of classical and non-classical anticoagulant heparan sulfate polysaccharides.},
  author={Balagurunathan Kuberan and David L. Beeler and Miroslaw Z Lech and Zhengliang Wu and Robert Rosenberg},
  journal={The Journal of biological chemistry},
  year={2003},
  volume={278 52},
  pages={52613-21}
}
Heparan sulfate (HS) polysaccharides interact with numerous proteins at the cell surface and orchestrate many different biological functions. Though many functions of HS are well established, only a few specific structures can be attributed to HS functions. The extreme diversity of HS makes chemical synthesis of specific bioactive HS structures a cumbersome and tedious undertaking that requires laborious and careful functional group manipulations. Now that many of the enzymes involved in HS… CONTINUE READING