Chemoenzymatic synthesis of CMP-N-acetyl-7-fluoro-7-deoxy-neuraminic acid.

@article{Hartlieb2008ChemoenzymaticSO,
  title={Chemoenzymatic synthesis of CMP-N-acetyl-7-fluoro-7-deoxy-neuraminic acid.},
  author={Sina Hartlieb and Almut G{\"u}nzel and Rita Gerardy-Schahn and Anja K. M{\"u}nster-K{\"u}hnel and Andreas Kirschning and Gerald Draeger},
  journal={Carbohydrate research},
  year={2008},
  volume={343 12},
  pages={2075-82}
}
7-Fluoro sialic acid was prepared and activated as cytidine monophosphate (CMP) ester. The synthesis started with d-glucose, which was efficiently converted into N-acetyl-4-fluoro-4-deoxy-d-mannosamine. Aldolase catalyzed transformation yielded the corresponding fluorinated sialic acid which was activated as CMP ester using three different synthetases in… CONTINUE READING