Chemoenzymatic preparation of all the stereoisomers of 2-(1-hydroxyethyl)- and 2,6-bis(1-hydroxyethyl)pyridines and their acetates

@inproceedings{Szatzker2004ChemoenzymaticPO,
  title={Chemoenzymatic preparation of all the stereoisomers of 2-(1-hydroxyethyl)- and 2,6-bis(1-hydroxyethyl)pyridines and their acetates},
  author={G{\'a}bor Szatzker and Ildik{\'o} M{\'o}cz{\'a}r and Pāl Kolonits and Lajos Nov{\'a}k and P{\'e}ter Huszthy and L{\'a}szl{\'o} Poppe},
  year={2004}
}
Abstract Several lipases were tested for the enantiomerically selective acetylation of racemic 1-[6-(1-hydroxyethyl)-pyridin-2-yl]ethanone rac - 2 to yield alcohol ( S )- 2 and acetate ( R )- 3 . Acetylation of a diastereomeric mixture of racemic and meso -2,6-bis(1-hydroxy-ethyl)pyridine, rac/meso - 4 , with the most selective Novozym 435 lipase in vinyl acetate resulted in a mixture of enantiopure diol ( S , S )- 4 , monoacetate ( R , S )- 5 and diacetate ( R , R )- 6 . Hydrolysis of the… CONTINUE READING