Chemoenzymatic iterative synthesis of difficult linkages of oligosaccharides on soluble polymeric supports.

@article{Yan2001ChemoenzymaticIS,
  title={Chemoenzymatic iterative synthesis of difficult linkages of oligosaccharides on soluble polymeric supports.},
  author={Fengyang Yan and Michel Gilbert and Warren W. Wakarchuk and J. R. Brisson and Dennis M. Whitfield},
  journal={Organic letters},
  year={2001},
  volume={3 21},
  pages={3265-8}
}
[reaction: see text]. A trisaccharide donor containing a cis-Galpalpha(1-->4)Galp linkage was prepared using a synthetic strategy based on chemoenzymatic oligosaccharide synthesis on a soluble polymeric support. Significantly, only retaining glycosyltransferases gave complete reactions, whereas inverting enzymes showed little or no activity with poly… CONTINUE READING