Chemoenzymatic Glyco-engineering of Monoclonal Antibodies.

Abstract

Monoclonal antibodies (mAbs) are an important class of therapeutic glycoproteins widely used for the treatment of cancer, inflammation, and infectious diseases. Compelling data have shown that the presence and fine structures of the conserved N-glycans at the Fc domain can profoundly affect the effector functions of antibodies. However, mAbs are usually… (More)
DOI: 10.1007/978-1-4939-2760-9_25

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