Chemoenzymatic Glycan Remodeling of Natural and Recombinant Glycoproteins.

Abstract

N-glycosylation plays important roles in modulating the biological functions of glycoproteins, such as protein folding, stability, and immunogenicity. However, acquiring homogeneous glycoforms of glycoproteins has been a challenging task for functional studies and therapeutic applications. In this chapter, we describe an efficient chemoenzymatic glycan… (More)
DOI: 10.1016/bs.mie.2017.06.006

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