Chemoattractant-induced cytoplasmic pH changes and cytoskeletal reorganization in human neutrophils. Relationship to the stimulated calcium transients and oxidative burst.

@article{Naccache1989ChemoattractantinducedCP,
  title={Chemoattractant-induced cytoplasmic pH changes and cytoskeletal reorganization in human neutrophils. Relationship to the stimulated calcium transients and oxidative burst.},
  author={Paul H. Naccache and S F Therrien and Adriana C Caon and N W Liao and Caroline Gilbert and Shaun R McColl},
  journal={Journal of immunology},
  year={1989},
  volume={142 7},
  pages={2438-44}
}
The relationships between the chemotactic factor-stimulated mobilization of calcium, activation of the NADPH-oxidase, changes in cytosolic pH, and in the level of polymerized actin in human neutrophils have been examined. The approach taken was to use intracellular calcium chelators, and pharmacologic modulators (both positive and negative) of the NADPH-oxidase to measure the aforementioned responses under conditions where the calcium transients were abrogated and/or the generation of… CONTINUE READING
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