Chemoattractant action and molecular signaling pathways of Kit ligand on mouse primordial germ cells.

@article{Farini2007ChemoattractantAA,
  title={Chemoattractant action and molecular signaling pathways of Kit ligand on mouse primordial germ cells.},
  author={Donatella Farini and Gina La Sala and Marianna Tedesco and Massimo De Felici},
  journal={Developmental biology},
  year={2007},
  volume={306 2},
  pages={572-83}
}
Using a Transwell chamber as migration assay for mouse primordial germ cells (PGCs), we show here that these cells posses directional migration in the absence of somatic cell and defined matrix support and in response to a Kit ligand (KL) gradient or medium conditioned by Aorta/Gonad/Mesonephros and gonadal ridges. Other putative PGC chemoattractants such as SDF1 and TGFbeta did not exert any attractive action on PGCs. The chemoattractant activity of KL and conditioned medium was also evidenced… CONTINUE READING

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