Chemo-mechanical model of a cell as a stochastic active gel
@article{Deshpande2021ChemomechanicalMO, title={Chemo-mechanical model of a cell as a stochastic active gel}, author={V. Deshpande and Antonio DeSimone and Robert M. McMeeking and Pierre Recho}, journal={Journal of The Mechanics and Physics of Solids}, year={2021}, volume={151}, pages={104381} }
8 Citations
Mechanical feedback in size regulation
- Materials Science
- 2023
The mechanism with which cells measure the dimension of the organ in which they are embedded, and slow down their growth when the final size is reached, is a long standing problem of developmental…
Chemo-transport-mechanics in advecting membranes
- EngineeringInternational Journal of Engineering Science
- 2022
Cell strain energy costs of active control of contractility
- Engineering, BiologybioRxiv
- 2022
Substrate strain energy would select for the observed clustering of cell adhesions on stiffer substrates which also enable an upregulation of total contractile pressure; while localisation of contractility has the greatest impact on the internal work.
How dynamic prestress governs the shape of living systems, from the subcellular to tissue scale
- BiologyInterface Focus
- 2022
A range of phenomena where prestress controls shape changes in biopolymer networks and cellularized tissues are described, demonstrating that these phenomena stem from a limited number of spatial distributions of prestress, which can be categorized as heterogeneous, anisotropic or differential.
Cell motility as an energy minimization process.
- PhysicsPhysical review. E
- 2022
It is shown that there exists a quasi-potential effectively describing the collective self-organization of the motors propelling a cell at a continuum active gel level, and such a model allows us to understand cell motility as an active phase transition problem between the static and motile steady state configurations that minimize the quasi-Potential.
Physical bioenergetics: Energy fluxes, budgets, and constraints in cells
- Biology, PhysicsProceedings of the National Academy of Sciences
- 2021
Physical bioenergetics, which resides at the interface of nonequilibrium physics, energy metabolism, and cell biology, seeks to understand how much energy cells are using, how they partition this energy between different cellular processes, and the associated energetic constraints.
Cell orientation under stretch: Stability of a linear viscoelastic model.
- Biology, EngineeringMathematical biosciences
- 2021
Mechanical Feedback in Regulating the Size of Growing Multicellular Spheroids
- Materials Science
- 2020
The mechanism by which cells measure the dimension of the organ in which they are embedded, and slow down their growth when the final size is reached, is a long-standing problem of developmental…
58 References
Modeling cell crawling strategies with a bistable model: From amoeboid to fan-shaped cell motion
- BiologyPhysica D: Nonlinear Phenomena
- 2020
Modeling random crawling, membrane deformation and intracellular polarity of motile amoeboid cells
- BiologyPloS one
- 2018
A mathematical model of amoeboid motility that combines noisy bistable kinetics with a dynamic phase field for the cell shape and introduces a single parameter for tuning the balance between polarity formation and intracellular noise to capture cell-to-cell variability.
On a poroviscoelastic model for cell crawling
- EngineeringJournal of mathematical biology
- 2015
This paper uses an upper-convected Maxwell model and demonstrates that even the simplest of two-phase, viscoelastic models displays features relevant to cell motility, and shows care must be exercised in choosing parameters for such models as a poor choice can lead to an ill–posed problem.
Scaling the microrheology of living cells.
- BiologyPhysical review letters
- 2001
A scaling law is reported that governs both the elastic and frictional properties of a wide variety of living cell types, over a wide range of time scales and under a variety of biological interventions, and implies that cytoskeletal proteins may regulate cell mechanical properties mainly by modulating the effective noise temperature of the matrix.
The homeostatic ensemble for cells
- Biology, Environmental ScienceBiomechanics and modeling in mechanobiology
- 2018
This work develops a statistical mechanics framework for living cells by including the homeostatic constraint that exists over the interphase period of the cell cycle, and argues that the observed variabilities are inherent to the entropic nature of the homestatic equilibrium of cells and not a result of in vitro experimental errors.
Cell motility as random motion: A review
- Engineering
- 2008
Abstract.The historical co-evolution of biological motility models with models of Brownian motion is outlined.
Recent results for how to derive cell-type-specific motility models from experimental…
Prediction of traction forces of motile cells
- BiologyInterface Focus
- 2016
A rheological model of actomyosin linking tension, deformation and myosin activity is validated and the basic pattern of traction forces is robustly predicted by the model and fixed parameters as a function of current geometry only.
Frontiers in bioengineering and biotechnology
- 2007