Chemistry of unprotected amino acids in aqueous solution: direct bromination of aromatic amino acids with bromoisocyanuric acid sodium salt under strong acidic condition.

@article{Yokoyama2006ChemistryOU,
  title={Chemistry of unprotected amino acids in aqueous solution: direct bromination of aromatic amino acids with bromoisocyanuric acid sodium salt under strong acidic condition.},
  author={Yuusaku Yokoyama and Tomotsugu Yamaguchi and Masanori Sato and Eri H Kobayashi and Yasuoki Murakami and Hiroaki Okuno},
  journal={Chemical & pharmaceutical bulletin},
  year={2006},
  volume={54 12},
  pages={1715-9}
}
Brominations of unprotected aromatic amino acids such as phenylalanine, tyrosine, and glycine, with bromoisocyanuric acid mono sodium salt (BICA-Na) were conducted in 60% aq. H(2)SO(4) at 0 degrees C to give a mixture of mono-brominated products in good yield. Unexpectedly, meta-bromophenylglycine was obtained as main product accompanied by ortho- and para-substituted products, while phenylalanine gave only ortho- and para-substituted products. Bromination of 2-phenylethylamine or benzylamine… CONTINUE READING