Chemistry of nitrosoureas. Intermediacy of 4,5-dihydro-1,2,3-oxadiazole in 1,3-bis(2-chloroethyl)-1-nitrosourea decomposition.


A new product, ethylene glycol, was identified from BCNU [1,3-bis(2-chloroethyl)-1-nitrosourea] decomposition. The variation of ethylene glycol yield with pH indicates that there are two competing mechanisms of decomposition. At pH 7.4 the decomposition is predominantly through 2-chloroethyldiazohydroxide, an chloroethanol and acetaldehyde are the major… (More)


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