Chemistry of ion coordination and hydration revealed by a K+ channel–Fab complex at 2.0 Å resolution

  title={Chemistry of ion coordination and hydration revealed by a K+ channel–Fab complex at 2.0 Å resolution},
  author={Y. Zhou and J. H. Morais-Cabral and A. Kaufman and R. MacKinnon},
  • Y. Zhou, J. H. Morais-Cabral, +1 author R. MacKinnon
  • Published 2001
  • Chemistry, Medicine
  • Nature
  • Ion transport proteins must remove an ion's hydration shell to coordinate the ion selectively on the basis of its size and charge. To discover how the K+ channel solves this fundamental aspect of ion conduction, we solved the structure of the KcsA K+ channel in complex with a monoclonal Fab antibody fragment at 2.0 Å resolution. Here we show how the K+ channel displaces water molecules around an ion at its extracellular entryway, and how it holds a K+ ion in a square antiprism of water… CONTINUE READING
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