Chemistry of heteroanalogs of isoflavones

  title={Chemistry of heteroanalogs of isoflavones},
  author={Volodymir P. Khilya and V. F. Vakulenko and I. P. Kupchevskaya},
  journal={Chemistry of Heterocyclic Compounds},
Thiazole analogs of isomeric isoflavones were synthesized from α-(2,4-dimethyl-5-thiazolyl)-2-hydroxyacetophenones, and their reaction with hydrazine hydrate and alkylating and acylating agents was studied. The reaction of thiazole derivatives of 7-hydroxychromone with hydrazine hydrate proceeds with opening of the pyrone ring and subsequent cyclization of the intermediate to o-hydroxyphenylpyrazole derivatives. The reaction of hydrazine hydrate with thiazole derivatives of 5-hydroxychromone… CONTINUE READING