Chemistry in living systems

@article{Prescher2005ChemistryIL,
  title={Chemistry in living systems},
  author={Jennifer A. Prescher and Carolyn R. Bertozzi},
  journal={Nature Chemical Biology},
  year={2005},
  volume={1},
  pages={13-21}
}
Dissecting complex cellular processes requires the ability to track biomolecules as they function within their native habitat. Although genetically encoded tags such as GFP are widely used to monitor discrete proteins, they can cause significant perturbations to a protein's structure and have no direct extension to other classes of biomolecules such as glycans, lipids, nucleic acids and secondary metabolites. In recent years, an alternative tool for tagging biomolecules has emerged from the… 

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