Chemistry and structure-activity relationship of HIV-1 integrase inhibitor integracide B and related natural products.

@article{Singh2003ChemistryAS,
  title={Chemistry and structure-activity relationship of HIV-1 integrase inhibitor integracide B and related natural products.},
  author={S. B. Singh and J. Ondeyka and W. Schleif and P. Felock and D. Hazuda},
  journal={Journal of natural products},
  year={2003},
  volume={66 10},
  pages={
          1338-44
        }
}
  • S. B. Singh, J. Ondeyka, +2 authors D. Hazuda
  • Published 2003
  • Chemistry, Medicine
  • Journal of natural products
  • Integracides, 4,4-dimethylergostane triterpenoids, are inhibitors of HIV-1 integrase, a critical enzyme in replication of HIV-1. The chemistry and structure-activity relationship of integracide B and related natural products are described. A charged group, e.g., a sulfate, carboxyl, or amino, is required for the HIV-1 integrase activity. These compounds showed HIV-1 integrase activity with IC(50) values in the range 4.8-15 muM and exhibited antiviral activity in a viral spread assay, but with… CONTINUE READING
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