Chemistry and biology of the aeruginosin family of serine protease inhibitors.

@article{Ersmark2008ChemistryAB,
  title={Chemistry and biology of the aeruginosin family of serine protease inhibitors.},
  author={Karolina Ersmark and Juan R Del Valle and Stephen Hanessian},
  journal={Angewandte Chemie},
  year={2008},
  volume={47 7},
  pages={
          1202-23
        }
}
The aeruginosins have been isolated from marine sponges and cyanobacterial waterblooms, sources that are phylogenetically distinct and the bodies of water are geographically well-separated. The aeruginosins comprise a central hydroxy- (or dihydroxy-) octahydroindole carboxamide core unit, onto which are appended unusual amino acids on the carboxy and amino termini as part of the linear peptide array. Potent inhibitory activity of serine proteases in vitro is exhibited by some of the… CONTINUE READING
1
Twitter Mention