Chemistry and Pharmacology of Anticancer Drugs

@inproceedings{Thurston2006ChemistryAP,
  title={Chemistry and Pharmacology of Anticancer Drugs},
  author={David E. Thurston},
  year={2006}
}
INTRODUCTION TO CANCER Terminology Metastases Diagnosis and Screening Formation of Cancer Cells (Tumorigenesis) Mechanisms of Genomic Damage Treatments Discovery of Anticancer Drugs and Preclinical Evaluation Accessibility of Drugs to Tumor Cells Achieving Selective Toxicity Limiting the Toxicity of Chemotherapeutic Agents Overview of Mechanisms of Action of Chemotherapeutic Agents Drug Resistance Combination Chemotherapy Use of Adjuvants Infertility Following Cancer Treatments ANTIMETABOLITES… 
Adverse reactions to targeted and non-targeted chemotherapeutic drugs with emphasis on hypersensitivity responses and the invasive metastatic switch
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Adverse reactions to 44 non-targeted and 33 targeted, frequently used, chemotherapeutic drugs are presented together with discussions of diagnosis, premedications, desensitizations and importance of understanding the mechanisms underlying the various drug-induced reactions.
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The current knowledge of all the chemical scaffolds, approved and/or investigational, utilized as inhibitors in lung cancer are revealed and the rationale of designing these along with possible interactions with their targets, biological data and possible problems associated with these inhibitors are explained.
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An overview of recent developments in the field of oligonucleotide therapeutics in oncology is provided, including results obtained in preclinical studies and clinical trials are encouraging, and associated challenges are discussed.
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The combination of CDK9 and CDK1 inhibition results in effective induction of apoptosis in cancer cells and suggests that CDKI-71 has a great potential to be developed as an anti-cancer agent.
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The cytotoxicity results from the study suggested that the synthesized molecules are potential antitumor agents and compound 4a was the most potent with an IC 50 2.04 nm.
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