Chemistry: Chemical con artists foil drug discovery

  title={Chemistry: Chemical con artists foil drug discovery},
  author={Jonathan Baell and Michael A. Walters},
Academic researchers, drawn into drug discovery without appropriate guidance, are doing muddled science. When biologists identify a protein that contributes to disease, they hunt for chemical compounds that bind to the protein and affect its activity. A typical assay screens many thousands of chemicals. ‘Hits’ become tools for studying the disease, as well as starting points in the hunt for treatments. But many hits are artefacts — their activity does not depend on a specific, drug-like… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 345 times over the past 90 days. VIEW TWEETS

From This Paper

Topics from this paper.


Publications citing this paper.
Showing 1-10 of 159 extracted citations

Similar Papers

Loading similar papers…