Chemistry: Chemical con artists foil drug discovery

@article{Baell2014ChemistryCC,
  title={Chemistry: Chemical con artists foil drug discovery},
  author={Jonathan Baell and Michael A. Walters},
  journal={Nature},
  year={2014},
  volume={513},
  pages={481-483}
}
Academic researchers, drawn into drug discovery without appropriate guidance, are doing muddled science. When biologists identify a protein that contributes to disease, they hunt for chemical compounds that bind to the protein and affect its activity. A typical assay screens many thousands of chemicals. ‘Hits’ become tools for studying the disease, as well as starting points in the hunt for treatments. But many hits are artefacts — their activity does not depend on a specific, drug-like… CONTINUE READING
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