Chemiosmotic coupling in energy transduction: A logical development of biochemical knowledge
@article{Mitchell1972ChemiosmoticCI, title={Chemiosmotic coupling in energy transduction: A logical development of biochemical knowledge}, author={Peter D. Mitchell}, journal={Journal of bioenergetics}, year={1972}, volume={3}, pages={5-24} }
At the invitation of the Editors, this paper gives a summary sketch of my position regarding some metabolic aspects of energy transduction and describes some present and anticipated perspectives from my point of view. To maintain as broad a horizon as possible, however, I have used this opportunity to describe how my views, and the rationale that I have developed to express them, have been derived from accepted or acceptable physicochemical theory and biochemical knowledge stemming from the…
218 Citations
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References
SHOWING 1-10 OF 43 REFERENCES
An evaluation of the Mitchell hypothesis of chemiosmotic coupling in oxidative and photosynthetic phosphorylation.
- BiologyEuropean journal of biochemistry
- 1967
Experimental evidence is presented confirming that, under the conditions of the oxygen-pulse experiments of Mitchell and Moyle, the extrusion of H+ is not associated with the oxidation of mitochondrial NADH, and the respiratory chain included in the chemiosmotic hypothesis is difficult to reconcile with present knowledge of the chain.
CHEMIOSMOTIC COUPLING IN OXIDATIVE AND PHOTOSYNTHETIC PHOSPHORYLATION
- ChemistryBiological reviews of the Cambridge Philosophical Society
- 1966
The end result of the coupling between the flows through the o/r and h/d pathways in oxidative phosphorylation in mitochondria is that, for the equivalent of each pair of electrons traversing the respiratory chain, up to 3 anhydro-bond equivalents may normally traverse the h/D pathway from adenosine diphosphate plus inorganic phosphate (ADP +Pi) to water.
ION TRANSPORT IN CHLOROPLASTS AND PLANT MITOCHONDRIA
- Biology
- 1970
The chemiosmotic hypothesis has made the most compelling arguments toward bringing a comprehensive picture into focus upon the various types of ion movements predictable from a hydrogen gradient as being the accompanying electron transport in energy transd ueing.
Chemical hypothesis for energy conservation in the mitochondrial respiratory chain.
- Biology, ChemistryJournal of theoretical biology
- 1970
Partial resolution of the enzymes catalyzing oxidative phosphorylation. XXIV. A factor required for the binding of mitochondrial adenosine triphosphatase to the inner mitochondrial membrane.
- Biology, ChemistryThe Journal of biological chemistry
- 1971
The effect of tonicity of the medium on the respiratory and phosphorylative activity of heart-muscle sarcosomes.
- BiologyThe Biochemical journal
- 1953
The present study was undertaken as part of an investigation of the optimal conditions for oxidative phosphorylation in heart-muscle sarcosomes, the granules which correspond to the mitochondria in other tissues.