Chemiosmotic coupling in energy transduction: A logical development of biochemical knowledge

@article{Mitchell1972ChemiosmoticCI,
  title={Chemiosmotic coupling in energy transduction: A logical development of biochemical knowledge},
  author={Peter D. Mitchell},
  journal={Journal of bioenergetics},
  year={1972},
  volume={3},
  pages={5-24}
}
  • P. Mitchell
  • Published 1 May 1972
  • Biology
  • Journal of bioenergetics
At the invitation of the Editors, this paper gives a summary sketch of my position regarding some metabolic aspects of energy transduction and describes some present and anticipated perspectives from my point of view. To maintain as broad a horizon as possible, however, I have used this opportunity to describe how my views, and the rationale that I have developed to express them, have been derived from accepted or acceptable physicochemical theory and biochemical knowledge stemming from the… 

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Experimental evidence is presented confirming that, under the conditions of the oxygen-pulse experiments of Mitchell and Moyle, the extrusion of H+ is not associated with the oxidation of mitochondrial NADH, and the respiratory chain included in the chemiosmotic hypothesis is difficult to reconcile with present knowledge of the chain.

CHEMIOSMOTIC COUPLING IN OXIDATIVE AND PHOTOSYNTHETIC PHOSPHORYLATION

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TLDR
The end result of the coupling between the flows through the o/r and h/d pathways in oxidative phosphorylation in mitochondria is that, for the equivalent of each pair of electrons traversing the respiratory chain, up to 3 anhydro-bond equivalents may normally traverse the h/D pathway from adenosine diphosphate plus inorganic phosphate (ADP +Pi) to water.

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