Cheminformatics Models for Inhibitors of Schistosoma mansoni Thioredoxin Glutathione Reductase

@inproceedings{Gaba2014CheminformaticsMF,
  title={Cheminformatics Models for Inhibitors of Schistosoma mansoni Thioredoxin Glutathione Reductase},
  author={Sonam Gaba and Salma Jamal and Open Source Drug Discovery Consortium and Vinod Scaria},
  booktitle={TheScientificWorldJournal},
  year={2014}
}
Schistosomiasis is a neglected tropical disease caused by a parasite Schistosoma mansoni and affects over 200 million annually. There is an urgent need to discover novel therapeutic options to control the disease with the recent emergence of drug resistance. The multifunctional protein, thioredoxin glutathione reductase (TGR), an essential enzyme for the survival of the pathogen in the redox environment has been actively explored as a potential drug target. The recent availability of small… CONTINUE READING
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