Chemically modified tetracyclines inhibit human melanoma cell invasion and metastasis

@article{Seftor1998ChemicallyMT,
  title={Chemically modified tetracyclines inhibit human melanoma cell invasion and metastasis},
  author={Richard E. B. Seftor and Elisabeth A. Seftor and Joseph E. De Larco and David E Kleiner and Jill Leferson and William G Stetler-Stevenson and Thomas F. McNamara and Lorne M. Golub and Mary J. C. Hendrix},
  journal={Clinical & Experimental Metastasis},
  year={1998},
  volume={16},
  pages={217-225}
}
Recent work has shown that chemically modified tetracyclines (CMTs) are potent inhibitors of matrix metal-loproteinase (MMP) activity, both in vitro and in vivo, which is distinct from their antimicrobial activities (Golub et al. Crit Rev Oral Biol Med, 2, 297-321, 1991; Ryan et al. Curr Opin Rheumatol, 8, 238-47, 1996). The process of tumor cell invasion requires MMP-mediated degradation of extracellular matrix barriers as a key step in the metastasic cascade. In this study, we examined the… CONTINUE READING
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