Chemically modified siRNA prolonged RNA interference in renal disease.

  title={Chemically modified siRNA prolonged RNA interference in renal disease.},
  author={Yoshitsugu Takabatake and Yoshitaka Isaka and Masayuki Mizui and Hiroshi Kawachi and Shiro Takahara and Enyu Imai},
  journal={Biochemical and biophysical research communications},
  volume={363 2},
BACKGROUND We previously demonstrated that transfection of synthetic short interfering RNAs (siRNAs) targeting against TGF-beta1 could be effective and therapeutic in silencing TGF-beta1 expression in glomerulus, thereby ameliorated the progression of matrix expansion in anti-Thy-1 model of glomerulonephritis. However, a major concern in applying RNAi to gene therapy is the prolonged existence of silencing potential in vivo. METHOD We examined the duration of siRNA stability in kidney and… CONTINUE READING
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