Chemically modified antigen preferentially elicits induction of Th1- like cytokine synthesis patterns in vivo

@article{Yang1993ChemicallyMA,
  title={Chemically modified antigen preferentially elicits induction of Th1- like cytokine synthesis patterns in vivo},
  author={X Yang and Randall S. Gieni and Tim R. Mosmann and Kent T HayGlass},
  journal={The Journal of Experimental Medicine},
  year={1993},
  volume={178},
  pages={349 - 353}
}
Differential activation of CD4+ T cell subsets in vivo leads to the development of qualitatively different effector responses. We identify an approach that allows selective activation of strongly Th1-dominated immune responses to protein antigens. Whereas in vivo administration of ovalbumin (OVA) induces cytokine synthesis that is neither Th1 nor Th2 dominated, administration of glutaraldehyde polymerized, high relative molecular weight OVA (OA-POL) leads to 20-fold increase in the ratio of… CONTINUE READING

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