Chemically-induced unscheduled DNA synthesis in primary rat hepatocyte cultures: a comparison with bacterial mutagenicity using 218 compounds.

@article{Probst1981ChemicallyinducedUD,
  title={Chemically-induced unscheduled DNA synthesis in primary rat hepatocyte cultures: a comparison with bacterial mutagenicity using 218 compounds.},
  author={Gregory S. Probst and ROBERT E. MCMAHON and Leo E. Hill and Clenn Thompson and J K Epp and S B Neal},
  journal={Environmental mutagenesis},
  year={1981},
  volume={3 1},
  pages={11-32}
}
The autoradiographic identification of unscheduled DNA synthesis (UDS) in primary cultures of adult rat hepatocytes (HPC) has been proposed as a predictive test for mutagens/carcinogens. To assess the predictive value of this test, results in the hepatocyte UDS assay were compared with data for bacterial mutagenicity using a modified Ames test. Over 200… CONTINUE READING