Chemically engineered sulfated glucans from rice bran exert strong antiviral activity at the stage of viral entry.

@article{Ray2013ChemicallyES,
  title={Chemically engineered sulfated glucans from rice bran exert strong antiviral activity at the stage of viral entry.},
  author={Bimalendu Ray and Corina Hutterer and Shruti S Bandyopadhyay and Kanika Ghosh and Udipta Ranjan Chatterjee and Sayani Ray and Isabel Zeittraeger and Sabrina Wagner and Manfred Marschall},
  journal={Journal of natural products},
  year={2013},
  volume={76 12},
  pages={2180-8}
}
Attachment and entry of many viruses are mediated by their affinity for polysaccharides present on the surface of target cells. In this paper, we demonstrate that sulfated glucans isolated from rice (Oryza sativa) can be utilized as experimental drugs exerting strong antiviral activity. In particular, oleum-DMF-based extraction is described as a procedure for the generation of chemically engineered glucans from commercially available rice bran. The one-step procedure has the potential to… CONTINUE READING