Chemically Modified Oligonucleotides Modulate an Epigenetically Varied and Transient Form of Transcription Silencing of HIV-1 in Human Cells

@inproceedings{Knowling2012ChemicallyMO,
  title={Chemically Modified Oligonucleotides Modulate an Epigenetically Varied and Transient Form of Transcription Silencing of HIV-1 in Human Cells},
  author={Stuart Knowling and Kenneth Stapleton and Anne-Marie W. Turner and Eugen Uhlmann and Thomas Lehmann and J{\"o}rg Vollmer and Kevin Morris},
  booktitle={Molecular therapy. Nucleic acids},
  year={2012}
}
Small noncoding RNAs (ncRNAs) have been shown to guide epigenetic silencing complexes to target loci in human cells. When targeted to gene promoters, these small RNAs can lead to long-term stable epigenetic silencing of gene transcription. To date, small RNAs have been shown to modulate transcriptional gene silencing (TGS) of human immunodeficiency virus type 1 (HIV-1) as well as several other disease-related genes, but it has remained unknown as to what extent particular chemistries can be… CONTINUE READING

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