Chemically-Induced DNA Damage, Mutagenesis, and Cancer

@inproceedings{Basu2018ChemicallyInducedDD,
  title={Chemically-Induced DNA Damage, Mutagenesis, and Cancer},
  author={Ashis K Basu and Takehiko Nohmi},
  booktitle={International journal of molecular sciences},
  year={2018}
}
A large fraction of human cancers arise from exposure to chemicals, although radiation, oxidation, and genetic factors play critical roles as well. DNA damage by these agents in a cell is an important first step in the process of carcinogenesis. DNA repair processes have evolved to repair these damages. However, replication of damaged DNA may occur frequently prior to repair, resulting in gene mutations and generation of altered proteins. Mutations in an oncogene, a tumor-suppressor gene, or a… CONTINUE READING

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