Chemically Homogenous Compounds with Antagonistic Properties at All α1-Adrenoceptor Subtypes but not β1-Adrenoceptor Attenuate Adrenaline-Induced Arrhythmia in Rats

@inproceedings{Pytka2016ChemicallyHC,
  title={Chemically Homogenous Compounds with Antagonistic Properties at All α1-Adrenoceptor Subtypes but not β1-Adrenoceptor Attenuate Adrenaline-Induced Arrhythmia in Rats},
  author={Karolina Pytka and Klaudia Lustyk and Elżbieta Żmudzka and Magdalena Kotańska and Agata Siwek and Małgorzata Zygmunt and Agnieszka Dziedziczak and Joanna Śniecikowska and Adrian Olczyk and Adam Gałuszka and Jarosław Śmieja and Anna Maria Waszkielewicz and Henryk Marona and Barbara Filipek and Jacek Sapa and Szczepan Mogilski},
  booktitle={Front. Pharmacol.},
  year={2016}
}
Studies proved that among all α1-adrenoceptors, cardiac myocytes functionally express only α1A- and α1B-subtype. Scientists indicated that α1A-subtype blockade might be beneficial in restoring normal heart rhythm. Therefore, we aimed to determine the role of α1-adrenoceptors subtypes (i.e., α1A and α1B) in antiarrhythmic effect of six structurally similar… CONTINUE READING