Chemical tumor-targeting of nanoparticles based on metabolic glycoengineering and click chemistry.

@article{Lee2014ChemicalTO,
  title={Chemical tumor-targeting of nanoparticles based on metabolic glycoengineering and click chemistry.},
  author={Sangmin Lee and Heebeom Koo and Jin Hee Na and Seung Jin Han and Hyun Su Min and Suyeong Lee and Sun Hwa Kim and Seok Hyun Yun and Seo jeong Jeong and Ick Chan Kwon and Kuiwon Choi and Kwangmeyung Kim},
  journal={ACS nano},
  year={2014},
  volume={8 3},
  pages={
          2048-63
        }
}
Tumor-targeting strategies for nanoparticles have been predominantly based on optimization of physical properties or conjugation with biological ligands. However, their tumor-targeting abilities remain limited and insufficient. Furthermore, traditional biological binding molecules have intrinsic limitations originating from the limited amount of cellular receptors and the heterogeneity of tumor cells. Our two-step in vivo tumor-targeting strategy for nanoparticles is based on metabolic… CONTINUE READING
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