Chemical transformation is not rate-limiting in the reaction catalyzed by Escherichia coli 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase.

@article{Li2002ChemicalTI,
  title={Chemical transformation is not rate-limiting in the reaction catalyzed by Escherichia coli 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase.},
  author={Yue Li and Yunchen Gong and Genbin Shi and Jaroslaw Blaszczyk and Xinhua Ji and Honggao Yan},
  journal={Biochemistry},
  year={2002},
  volume={41 27},
  pages={8777-83}
}
6-Hydroxymethyl-7,8-dihydropterin pyrophosphokinase (HPPK) catalyzes the transfer of pyrophosphate from ATP to 6-hydroxymethyl-7,8-dihydropterin (HMDP). Because HPPK is essential for microorganisms but is absent from human and animals, the enzyme is an excellent target for developing antimicrobial agent. Thermodynamic analysis shows that Mg(2+) is important… CONTINUE READING