Chemical tags for labeling proteins inside living cells.

  title={Chemical tags for labeling proteins inside living cells.},
  author={Chaoran Jing and Virginia W Cornish},
  journal={Accounts of chemical research},
  volume={44 9},
To build on the last century's tremendous strides in understanding the workings of individual proteins in the test tube, we now face the challenge of understanding how macromolecular machines, signaling pathways, and other biological networks operate in the complex environment of the living cell. The fluorescent proteins (FPs) revolutionized our ability to study protein function directly in the cell by enabling individual proteins to be selectively labeled through genetic encoding of a… CONTINUE READING
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