Chemical tagging and customizing of cellular chromatin states using ultrafast trans-splicing inteins

@inproceedings{David2015ChemicalTA,
  title={Chemical tagging and customizing of cellular chromatin states using ultrafast trans-splicing inteins},
  author={Yael David and Miquel Vila-Perell{\'o} and Shivam Verma and Tom W Muir},
  booktitle={Nature chemistry},
  year={2015}
}
Post-translational modification of the histone proteins in chromatin plays a central role in the epigenetic control of DNA-templated processes in eukaryotic cells. Developing methods that enable the structure of histones to be manipulated is, therefore, essential to understand the biochemical mechanisms that underlie genomic regulation. Here we present a synthetic biology method to engineer histones that bear site-specific modifications on cellular chromatin using protein trans-splicing (PTS… CONTINUE READING
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