Chemical synthesis of an artificial antigen containing the trisaccharide hapten of Mycobacterium leprae.

@article{Marinoalbernas1988ChemicalSO,
  title={Chemical synthesis of an artificial antigen containing the trisaccharide hapten of Mycobacterium leprae.},
  author={J. R. Marino-albernas and vicente Verez-Bencomo and L L Gonz{\'a}lez-Rodr{\'i}guez and Carlos P{\'e}rez-Mart{\'i}nez and E Gonzalez-Abreu Castell and A Gonz{\'a}lez-Segredo},
  journal={Carbohydrate research},
  year={1988},
  volume={183 2},
  pages={
          175-82
        }
}
19 Citations
The carbohydrate- and lipid-containing cell wall of mycobacteria, phenolic glycolipids: structure and immunological properties.
  • G. Puzo
  • Biology, Chemistry
    Critical reviews in microbiology
  • 1990
TLDR
The search of immunoreactive glycolipids and their function analysis remain a challenge for chemists and immunologists for the understanding of the mycobacteria pathogenicity.
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3,6-di-O-methyl-beta-D-glucopyranose in its cyclic hemiacetal form is necessary for binding anti-glycolipid IgM from leprosy patients and the prospects of a fully synthetic specific antigen for the worldwide serodiagnosis of lepropsy look promising.
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A synthetic conjugate which contains the intact disaccharide region of PG-I may provide the most sensitive antigen for the large scale serodiagnosis of leprosy.
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Findings suggest that the cross-reactivity is associated with the phenol ring and implies the disaccharide may be a unique antigenic determinant of M. leprae.
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TLDR
It is shown that a unique antigen of M. leprae is capable of inducing suppression of mitogenic responses of lepromatous patients' lymphocytes in vitro and evidence that the suppressor T cells recognize the specific terminal trisaccharide moiety is provided.
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