Chemical synthesis of an artificial antigen containing the trisaccharide hapten of Mycobacterium leprae.

  title={Chemical synthesis of an artificial antigen containing the trisaccharide hapten of Mycobacterium leprae.},
  author={J. R. Marino-albernas and vicente Verez-Bencomo and L L Gonz{\'a}lez-Rodr{\'i}guez and Carlos P{\'e}rez-Mart{\'i}nez and E Gonzalez-Abreu Castell and A Gonz{\'a}lez-Segredo},
  journal={Carbohydrate research},
  volume={183 2},
19 Citations
The carbohydrate- and lipid-containing cell wall of mycobacteria, phenolic glycolipids: structure and immunological properties.
  • G. Puzo
  • Biology, Chemistry
    Critical reviews in microbiology
  • 1990
The search of immunoreactive glycolipids and their function analysis remain a challenge for chemists and immunologists for the understanding of the mycobacteria pathogenicity.


Use of an artificial antigen containing the 3,6-di-O-methyl-beta-D-glucopyranosyl epitope for the serodiagnosis of leprosy.
3,6-di-O-methyl-beta-D-glucopyranose in its cyclic hemiacetal form is necessary for binding anti-glycolipid IgM from leprosy patients and the prospects of a fully synthetic specific antigen for the worldwide serodiagnosis of lepropsy look promising.
Use of synthetic glycoconjugates containing the Mycobacterium leprae specific and immunodominant epitope of phenolic glycolipid I in the serology of leprosy.
A synthetic conjugate which contains the intact disaccharide region of PG-I may provide the most sensitive antigen for the large scale serodiagnosis of leprosy.
Analysis of the major antigenic determinants of the characteristic phenolic glycolipid from Mycobacterium leprae.
Findings suggest that the cross-reactivity is associated with the phenol ring and implies the disaccharide may be a unique antigenic determinant of M. leprae.
Lymphocyte suppression in leprosy induced by unique M. leprae glycolipid
It is shown that a unique antigen of M. leprae is capable of inducing suppression of mitogenic responses of lepromatous patients' lymphocytes in vitro and evidence that the suppressor T cells recognize the specific terminal trisaccharide moiety is provided.