Chemical synthesis and characterization of ShK toxin: a potent potassium channel inhibitor from a sea anemone.

@article{Pennington1995ChemicalSA,
  title={Chemical synthesis and characterization of ShK toxin: a potent potassium channel inhibitor from a sea anemone.},
  author={M W Pennington and Michael E. Byrnes and I. Zaydenberg and I. Khaytin and J de Chastonay and Douglas S. Krafte and Rowland Hill and Vladimir M. Mahnir and Walter A. Volberg and Wojciech Gorczyca},
  journal={International journal of peptide and protein research},
  year={1995},
  volume={46 5},
  pages={
          354-8
        }
}
ShK-toxin, a 35 residue peptide isolated from the sea anemone Stichodactyla helianthus, was synthesized using an Fmoc strategy and successfully folded to the biologically active form containing three intramolecular disulfide bonds. The ability of synthetic ShK toxin to inhibit specific [125I]-dendrotoxin I binding to rat brain membranes slightly exceeded (was more potent than) that of the natural ShK toxin sample, but was comparable with previously reported data for ShK toxin. The peptide toxin… CONTINUE READING

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