Chemical sympathectomy and postganglionic nerve transection produce similar increases in galanin and VIP mRNA but differ in their effects on peptide content.

@article{HyattSachs1996ChemicalSA,
  title={Chemical sympathectomy and postganglionic nerve transection produce similar increases in galanin and VIP mRNA but differ in their effects on peptide content.},
  author={H Hyatt-Sachs and M Bachoo and Rebecca C Schreiber and Stacey A Vaccariello and Richard E Zigmond},
  journal={Journal of neurobiology},
  year={1996},
  volume={30 4},
  pages={543-55}
}
Large changes in neuronal gene expression occur in adult peripheral neurons after axonal transection. In the rat superior cervical ganglion, for example, neurons that do not normally express vasoactive intestinal peptide (VIP) or galanin do so after postganglionic nerve transection. These effects of axotomy could result from a number of aspects of the surgical procedure. To test the idea that the important variable might be the disconnection of axotomized neuronal cell bodies from their target… CONTINUE READING