Chemical sympathectomy and maternal separation affect neonatal stress responses and adrenal sensitivity to ACTH.

@article{Walker1995ChemicalSA,
  title={Chemical sympathectomy and maternal separation affect neonatal stress responses and adrenal sensitivity to ACTH.},
  author={Claire-Dominique Walker},
  journal={The American journal of physiology},
  year={1995},
  volume={268 5 Pt 2},
  pages={R1281-8}
}
The participation of sympathetic adrenal innervation in the control of the neonatal adrenocortical system and in changes in adrenal sensitivity after maternal separation for 24 h was tested in 10- and 23-day-old pups. Chemical sympathectomy by guanethidine (20 mg/kg body wt) decreased basal and stimulated corticosterone compound B (B) secretion without affecting adrenocorticotropic hormone (ACTH) release, abolished the enhanced adrenal sensitivity to ACTH induced by maternal separation in 10… CONTINUE READING

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