Chemical structure of lipopolysaccharides and endotoxin immunity.

  title={Chemical structure of lipopolysaccharides and endotoxin immunity.},
  author={Ernst Th. Rietschel and Otto L{\"u}deritz},
  journal={Zeitschrift fur Immunitatsforschung, experimentelle und klinische Immunologie},
  volume={149 2-4},
Lipopolysaccharides (endotoxins) of gram-negative bacteria consist of 2 components with distinct physico-chemical character: a heteropolysaccharide and a covalently linked lipid, termed lipid A. The chemical structure of lipid A, which represents the toxic center of lipopolysaccharides, is discussed. Evidence is presented that lipid A antiserum suppresses… CONTINUE READING