Chemical structure and sympathomimetic action of amines

@article{BargerChemicalSA,
  title={Chemical structure and sympathomimetic action of amines},
  author={George W. Barger and Henry Hallett Dale},
  journal={The Journal of Physiology},
  volume={41}
}
Introductory. The elucidation of the structure of the active principle of the stupra-renal medulla by the work of Abell, v. Fifirth2, Takamine3, Aldrich4, Pauly5, and Jowett6, and its synthesis by Stolz 7 and by Dakin8, almost simultaneously, led to the physiological investigation of substances nearly related to it in chemical structure. Loewi and Meyer9, working with Stolz's preparations, investigated a number of ketones of the general formula (OH)2C5H3 . CO . CH2NR1R2 and the corresponding… 
THE CENTRAL ACTION OF BETAAMINOPROPYLBENZENE (BENZEDRINE): CLINICAL OBSERVATIONS
Beta-aminopropylbenzene (benzedrine) is a compound of the epinephrine series resembling ephedrine in chemical constitution, as shown in the structural formula. In 1910 Barger and Dale1made an
The change in pharmacological action produced by the introduction of a methyl group into priscol.
  • C. W. Gowdey
  • Chemistry
    British journal of pharmacology and chemotherapy
  • 1948
Within the last decade a new series of chemical compounds, the 2-substituted imidazolines, have claimed wide attention because of their vascular actions. Several of them, phedracin, priscol, privine
Classification of Sympathomimetic Amines
TLDR
A parallel to this “cocaine paradox” was observed after chronic sympathetic denervation, a procedure which potentiates the effects of adrenaline and antagonizes those of tyramine.
The structure of substances which affect the autonomic nervous system. I. Arylvinylamines.
  • G. P. Hager, K. H. Stahl
  • Chemistry
    Journal of the American Pharmaceutical Association. American Pharmaceutical Association
  • 1953
TLDR
Two arylvinylamines, prepared in an attempt to probe the reality of the of the hypothetical considerations, have been shown in preliminary pharmacologic tests to produce a rather prolonged fall in blood pressure and, following dibenamine, to exert a profound stimulatory effect of considerable duration on both the rate and amplitude of respiration.
The Selective Action of Drugs on Nerve-Endings
  • W. E. Dixon
  • Chemistry, Biology
    Proceedings of the Royal Society of Medicine
  • 1913
TLDR
The action of strong sulphuric acid in charring organic matter is the same in living and dead tissues, and depends upon the affinity of this acid for water.
THE STIMULATING ACTION OF BENZEDRINE SULFATE: A COMPARATIVE STUDY OF THE RESPONSES OF NORMAL PERSONS AND OF DEPRESSED PATIENTS
TLDR
Benzedrine was given prominence as an astringent to the human nasal mucosa, chiefly through the work of Bertolet, Byrne, 8 Scarano 9 and Wood.
The effect of changes in molecular configuration on inhibitory sympathomimetic action
  • A. M. Lands, M. Tainter
  • Chemistry
    Naunyn-Schmiedebergs Archiv für experimentelle Pathologie und Pharmakologie
  • 2004
TLDR
It was shown that the substance l iberated upon s t imula t ion of sympathe t ic nerves has properties identical to those of epinephrine.
Quaternized Sympathomimetic Amines
TLDR
It is found that the trimethylammonium derivative of dopamine had a stronger nicotine -like action, about as strong as nicotine itself.
STRUCTURE AND ACTIVITY RELATIONSHIPS OF MONOAMINE OXIDASE INHIBITORS
TLDR
By chemically manipulating these endogenous substances the authors had been able to hand-control certain bodily processes that had begun to malfunction because of a breakdown in the once carefully balanced automatic control mechanism (homeostatic equilibrium) of the body.
Influence of chain-length upon some pharmacological properties of S-alkyl isothioureas.
This study is one of a series in which an attempt has been made to explain, as far as possible in physicochemical terms, the distribution of certain pharmacological properties amongst isothioureas
...
...