Chemical structure and biologic activity of bacterial and synthetic lipid A.

@article{Rietschel1987ChemicalSA,
  title={Chemical structure and biologic activity of bacterial and synthetic lipid A.},
  author={Ernst Th. Rietschel and Lore Brade and Klaus Brandenburg and H. D. Flad and J de Jong-Leuveninck and Kiyomi Kawahara and Buko Lindner and Harald Loppnow and T L{\"u}deritz and Ulrich Schade},
  journal={Reviews of infectious diseases},
  year={1987},
  volume={9 Suppl 5},
  pages={S527-36}
}
The chemical structure of the lipid A component of enterobacterial lipopolysaccharide (LPS) is now known in some detail. For example, lipid A of Escherichia coli consists of a beta(1----6)-linked D-glucosamine disaccharide that carries four (R)-3-hydroxytetradecanoyl groups in positions 2, 3, 2', and 3' and two phosphoryl residues in positions 1 and 4'. The hydroxy fatty acids at positions 2' and 3' are acylated at their 3-hydroxyl groups by dodecanoic acid and tetradecanoic acid, respectively… CONTINUE READING

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