Chemical strategies for tagging and imaging the proteome.

  title={Chemical strategies for tagging and imaging the proteome.},
  author={Kimberly E Beatty},
  journal={Molecular bioSystems},
  volume={7 8},
Proteomic visualization serves as a complement to proteomic identification. In recent years, chemical biologists have made rapid progress developing new methods to tag and image defined sets of proteins. These researchers have requisitioned cellular machinery to place small, reactive analogues into biomolecules. The analogue has been labeled subsequently using a selective ligation reaction. Many groups have demonstrated the efficacy of the copper-catalyzed or strain-promoted azide-alkyne… CONTINUE READING
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