Chemical stability of adapalene and tretinoin when combined with benzoyl peroxide in presence and in absence of visible light and ultraviolet radiation

@article{Martin1998ChemicalSO,
  title={Chemical stability of adapalene and tretinoin when combined with benzoyl peroxide in presence and in absence of visible light and ultraviolet radiation},
  author={Martin and Meunier and Montels and Watts},
  journal={British Journal of Dermatology},
  year={1998},
  volume={139}
}
  • Martin, Meunier, Watts
  • Published 1 September 1998
  • Chemistry
  • British Journal of Dermatology
Adapalene and tretinoin are molecules used in the topical treatment of acne vulgaris. Commercial formulations (adapalene 0·1% gel and tretinoin 0·025% gel) were mixed with equal volumes of commercially available benzoyl peroxide formulation (10% lotion) and subsequently exposed to light over 24 h. With and without exposition to light, adapalene exhibits a remarkable stability whereas tretinoin is very sensitive to light and oxidation. The combination of benzoyl peroxide and light results in… 
View on Wiley
ncbi.nlm.nih.gov
97 Citations
Highly Influential Citations
1
Background Citations
15
Methods Citations
2

97 Citations

Citation Type

Citation Type

The stability of tretinoin in tretinoin gel microsphere 0.1%.
TLDR
The data suggest that the tretinoin gel microsphere 0.1% formulation offers marked protection against t retinoin photo degradation, even in the presence of a strong oxidizing agent such as benzoyl peroxide.
The effect of simulated solar UV irradiation on tretinoin in tretinoin gel microsphere 0.1% and tretinoin gel 0.025%.
TLDR
The investigation revealed that the TGM formulation offers marked protection against tretinoin photodegradation compared with TG, even in the presence of a topical gel containing a potent antibiotic or a strong oxidizing agent.
An overview of adapalene and benzoyl peroxide once-daily topical gel as a therapeutic option for acne
TLDR
Adapalene/benzoyl peroxide gel is safe and highly effective in the treatment of acne vulgaris and its efficacy, tolerability, and ease-of-use are superior to other topical acne therapies, and its use does not contribute to antibiotic resistance.
Emulsion containing at least one retinoid and benzoyl peroxide
TLDR
Invention provides high stability of the composition and represents a composition for prevention or treatment of dermatological diseases associated with disturbed cell differentiation and/ or proliferation and/or keratinisation.
Adapalene gel 0.3%: a novel topical retinoid formulation for acne vulgaris
TLDR
The primary advantage of the new 0.3% strength is increased efficacy, specifically for inflammatory lesions, but at a cost of slightly increased skin dryness during the initiation period.
A North American study of adapalene-benzoyl peroxide combination gel in the treatment of acne.
TLDR
A fixed-dose combination gel with adapalene 0.1% and benzoyl peroxide 2.5% recently has been developed for the treatment of acne vulgaris and has shown superiority in efficacy compared with adAPalene and BPO monotherapies and vehicle, with an early onset of efficacy and a good safety profile.
Adapalene–benzoyl peroxide, a unique fixed‐dose combination topical gel for the treatment of acne vulgaris: a transatlantic, randomized, double‐blind, controlled study in 1670 patients
TLDR
A unique, topical, fixed‐dose combination gel with adapalene 0·1% and benzoyl peroxide 2·5% has recently been developed for the once‐daily treatment of acne.
Synergistic efficacy of adapalene 0.1%-benzoyl peroxide 2.5% in the treatment of 3855 acne vulgaris patients
TLDR
The fixed-dose adapalene-BPO combination gel provides synergistic and significantly greater efficacy than its monotherapies in the treatment of acne vulgaris.
BENZOYL PEROXDE FOR TREATING ACNE LESIONS
  • Medicine
  • 2017
TLDR
Skin Tolerance of Adapalene 0.1% Gel in Combination with other Topical Antiacne Treatments' Journal of the American Academy of Dermatology Jun. 1997 to 2005, and clinical experience results with Clindamycin 1% Benzoyl Peroxide 5% Gel (Duac) as Monotherapy and in Com bination 2005.
Tretinoin photostability: comparison of micronized tretinoin gel 0.05% and tretinoin gel 0.025% following exposure to fluorescent and solar light.
TLDR
There is a body of evidence that supports the observation that certain vehicle formulations may reduce the potential for photodegradation of tretinoin, and a micronized aqueous-based formulation as well as a conventional gel showed minimal degradation when exposed to fluorescent light over eight hours.
...
1
2
3
4
5
...