Corpus ID: 20016395

Chemical speciation of binary complexes of embelin with some biologically important metal ions.

@article{Rani2010ChemicalSO,
  title={Chemical speciation of binary complexes of embelin with some biologically important metal ions.},
  author={V. Rani and G. Jyothi and G. N. Rao and B. Sailaja},
  journal={Acta chimica Slovenica},
  year={2010},
  volume={57 4},
  pages={
          916-21
        }
}
Protonation and complexation equilibria of embelin were investigated in 86% v/v dimethyl sulphoxide - water mixture electrometrically at an ionic strength of 0.17 mol dm-3 and at a temperature of 303K. The best fit chemical models were arrived at based on statistical grounds employing crystallographic R factor, χ2, skewness and kurtosis. The existence of binary complex species with Co(II), Ni(II), Cu(II) and Zn(II) were established from modeling studies using the computer program MINIQUAD75… Expand
Antibacterial Activity of Some Synthesized Metal Complexes of Embelin
The antimicrobial activity of embelin (2,5 dihydroxy 3-undecylp-benzoquinone) and its complexes with Co(II), Ni(II), Cu(II) and Zn(II) have been evaluated against Staphylococcus aureus andExpand
Novel series of benzoquinones with high potency against 5-lipoxygenase in human polymorphonuclear leukocytes.
TLDR
Interestingly, conversion to 1,2-benzoquinone and bimethylation of the hydroxyl moieties strongly improves 5-LO inhibition in polymorphonuclear leukocytes versus 2 up to 60-fold, exemplified by the C12-n-alkyl derivative 22c as highly potent 5- LO-selective lead compound in intact cells that warrants further preclinical evaluation as anti-inflammatory agent. Expand
Potent inhibition of human 5-lipoxygenase and microsomal prostaglandin E₂ synthase-1 by the anti-carcinogenic and anti-inflammatory agent embelin.
TLDR
Embelin potently suppressed the biosynthesis of eicosanoids by selective inhibition of 5-LO and mPGES-1 with IC₅₀=0.06 and 0.2 μM, which suggests embelin as novel chemotype for development of dual 5- LO/mPGes-1 inhibitors. Expand

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