Chemical shift imprint of intersubunit communication in a symmetric homodimer.

Abstract

Allosteric communication is critical for protein function and cellular homeostasis, and it can be exploited as a strategy for drug design. However, unlike many protein-ligand interactions, the structural basis for the long-range communication that underlies allostery is not well understood. This lack of understanding is most evident in the case of classical… (More)
DOI: 10.1073/pnas.1604748113

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