Chemical robotics — chemotactic drug carriers

  title={Chemical robotics — chemotactic drug carriers},
  author={Istv{\'a}n Lagzi},
  journal={Central European Journal of Medicine},
  • I. Lagzi
  • Published 11 January 2013
  • Biology
  • Central European Journal of Medicine
In this review we show and describe a concept of designing autonomously moving artificial cells (chemical robots) carrying drugs and having tactic behavior based on artificial chemotaxis. Such systems could help to provide new and more efficient drug delivery applications. Chemical robot can be constructed based on the self-organization — natural “bottom-up” way — of fatty acid or lipid molecules into ordered nano- or micrometer size objects that have the ability to move and respond to… Expand

Figures and Tables from this paper

Peptide-Metal Organic Framework Swimmers that Direct the Motion toward Chemical Targets.
A new intelligent biochemical swimmer is created by integrating metal organic frameworks (MOFs) and peptides that can sense toxic heavy metals in solution and swim toward the targets. Expand
Chemotaxis and Chemokinesis of Living and Non-living Objects
One of the fundamental properties of living organisms is the ability to sense and respond to changes in their environment by movement. If a motile cell senses soluble molecules and follows along aExpand
Nanorobotics in Drug Delivery Systems for Treatment of Cancer: A Review
This review aims at giving an overview of the present status of nanorobotics in cancer therapy. With the aid of biotechnology, molecular biology (as engineered organism) and molecular medicine canExpand
An experimental nanomedical platform for controller validation on targeted drug delivery
An experimental platform that simulates the circulatory system: the passing of blood from arteries to smaller blood vessels, while also capturing the non-Newtonian characteristic of the blood. Expand
Compartmentalizing Cell-Free Systems: Toward Creating Life-Like Artificial Cells and Beyond.
It is shown how compartmentalization and cell-free systems have, and will, come together to fulfill the goal to assemble a fully synthetic cell that displays functionality and complexity as advanced as that in nature. Expand
Evolution of Self-Propelled Objects: From the Viewpoint of Nonlinear Science.
This Minireview can help chemists in investigating self-propelled objects displaying various functional motions observed in a biological system by combining the dynamical information about these characteristic motions with the knowledge of molecular structures. Expand
Specific and Reversible DNA-Directed Self-Assembly of Modular Vesicle-Droplet Hybrid Materials.
This work functionalized giant unilamellar vesicles and emulsion droplets with biotinylated single-stranded DNA oligonucleotides using streptavidin as an intermediary linker to demonstrate specific and reversible DNA-directed self-assembly into vesicle-droplet hybrid structures. Expand
A hydrodynamic-stochastic model of chemotactic ciliated microorganisms
The mean first passage time is calculated, by varying the strength of the chemical gradient and the adaptation time, to determine the success rate of chemotaxis. Expand
Coupled RapidCell and lattice Boltzmann models to simulate hydrodynamics of bacterial transport in response to chemoattractant gradients in confined domains
The RapidCell (RC) model was originally developed to simulate flagellar bacterial chemotaxis in environments with spatiotemporally varying chemoattractant gradients. RC is best suited for motilityExpand
Challenges for Nanotechnology
The term “Nanotechnology” describes a large field of scientific and technical activities dealing with objects and technical components with small dimensions. Typically, bodies that are in–atExpand


Chemical locomotion.
Key to the design of nano- and micromotors is the asymmetric placement of the catalyst: its placement in an environment containing a suitable substrate translates into non-uniform consumption of the substrate and distribution of reaction products, which results in the motility of the object. Expand
Autonomously Moving Colloidal Objects that Resemble Living Matter
This article reviews several examples of systems with significant characteristics such as transduction of chemical potential into work without heat, chemosensitive motion, chemotactic and phototactic motions, and pulse-like motion with periodicities responding to the chemical environment, focusing on chemical systems containing amphiphilic molecules. Expand
Rapid delivery of drug carriers propelled and navigated by catalytic nanoshuttles.
Ability of nanomotors to rapidly deliver drug-loaded polymeric particles and liposomes to their target destination represents a novel approach towards transporting drug carriers in a target-specific manner and potentially addresses the obstacles of current nanoparticle drug delivery. Expand
Active targeting in a random porous medium by chemical swarm robots with secondary chemical signaling.
The results demonstrate that the selected performance criteria (the localization half time and the success rate) can be improved when an appropriate signaling process is chosen and the topological complexity of the porous environment needs to be reflected. Expand
A polymerization-powered motor.
The first motor to be powered by a polymerization reaction outside biological systems is presented, powered by ringopening metathesis polymerization (ROMP) of norbornene and exhibited the phenomenon of chemotaxis when placed in a monomer gradient; an extremely rare example outside biology. Expand
Molecular vehicles for targeted drug delivery.
A novel strategy for assembly of drug delivery vehicles that does not require chemical modification of targeting proteins is described, which relies on a noncovalent binding of standardized "payload" modules to targeting proteins expressed with a "docking" tag. Expand
Nanorobot: A versatile tool in nanomedicine
The first operating biological nanorobots are expected to appear in the coming 5 years and more complex diamondoid based nan orobots will become available in about 10 years, which means a very near better future with significant improvements in medicine. Expand
Biomimetic behavior of synthetic particles: from microscopic randomness to macroscopic control.
The current progress in establishing autonomous motion of micro/nano-particles that possess controlled randomness is reviewed, insight is provided into the phenomena where macroscopic order originates from microscopic disorder and the resemblance between these artificial systems and biological emergent/collective behaviors is discussed. Expand
Nanotechnology, nanomedicine and nanosurgery.
  • R. Freitas
  • Medicine
  • International journal of surgery
  • 2005
It is proposed that someday nanorobots will be able to travel through the body searching out and clearing up diseases, such as an arterial atheromatous plaque, as well as the potential medical applications of this new technology. Expand
Cell-based drug delivery.
Cell based delivery systems, especially erythrocyte-based, are especially efficient in releasing drugs in circulations for weeks, have a large capacity, can be easily processed and could accommodate traditional and biologic drugs. Expand