Chemical reprogramming of Caenorhabditis elegans germ cell fate

  title={Chemical reprogramming of Caenorhabditis elegans germ cell fate},
  author={Clinton T. Morgan and Myon-Hee Lee and Judith Kimble},
  booktitle={Nature chemical biology},
Small molecules can control cell fate in vivo and may allow directed induction of desired cell types, providing an attractive alternative to transplant-based approaches in regenerative medicine. We have chemically induced functional oocytes in Caenorhabditis elegans adults that otherwise produced only sperm. These findings suggest that chemical approaches to therapeutic cell reprogramming may be feasible and provide a powerful platform for analyzing molecular mechanisms of in vivo cell… CONTINUE READING