Chemical reactivity in solid-state pharmaceuticals: formulation implications.

  title={Chemical reactivity in solid-state pharmaceuticals: formulation implications.},
  author={Stephen Robert Byrn and Weiwei Xu and Ann W. Newman},
  journal={Advanced drug delivery reviews},
  volume={48 1},
Solid-state reactions that occur in drug substances and formulations include solid-state phase transformations, dehydration/desolvation, and chemical reactions. Chemical reactivity is the focus of this chapter. Of particular interest are cases where the drug-substance may be unstable or react with excipients in the formulation. Water absorption can enhance molecular mobility of solids and lead to solid-state reactivity. Mobility can be measured using various methods including glass transition… CONTINUE READING
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